I'm sure it can. I just have an issue with applying pesticide to my dogs period. So - I would be reluctant in any circumstance with putting it on a puppy.Frontline can be used on puppies @ 8 weeks old
Why do you keep it in the refrigerator? There is no exp. date.I noticed the same difficulty (mainly in the fur) so developed this procedure:
We use some disposable rubber gloves (about 100 or so to a package). I warm up the Frontline+ by putting its dispenser in warm water for about 10 minutes before applying just to cut down on any squirming by Puff. (I keep our Frontline+ in the refrigerator.)
Then I break open the applicator end, spread the fur and press it fairly firmly against the skin in the between-the-shoulders area and squeeze.
Then I rub the area to insure that any liquid on her fur has also rubbed against her skin.